产品说明
一般描述
Cadherin 22, type 2 (CDH22) belongs to cadherin family. Cadherins are transmembrane proteins. They contain an extracellular domain responsible for cell-cell binding, a transmembrane domain and a cytoplasmic domain.
免疫原
Synthetic peptide directed towards the N terminal region of human CDH22
应用
Anti-CDH22 antibody produced in rabbit is suitable for western blotting at a concentration of 5.0μg/ml.
生化/生理作用
Cadherin 22, type 2 (CDH22) is a calcium-dependent cell adhesion protein expressed highly in the brain. Functions of CDH22 include morphogenesis in neural and non-neural cells during the development of brain and the neuroendocrine organs. CDH22 interacts directly with PRL3 (Protein-tyrosine phosphatase of regenerating liver 3), gene responsible for promotion of epithelial mesenchymal transition. PRL3 results in down-regulation of CDH22 expression. CDH22 is up-regulated in colorectal cancer and lymphatic metastasis of colorectal carcinoma. Absence of CDH22 partially suppresses proliferation of colorectal cancer cells.
序列
Synthetic peptide located within the following region: LIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQD
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 73 kDa |
| species reactivity | mouse, human, rat, dog, guinea pig, horse, rabbit, bovine |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_067071 |
| UniProt登记号 | Q9UJ99 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CDH22(64405) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
