Anti-CCBP2 antibody produced in rabbit

产品说明

一般描述

CCBP2 is a β chemokine receptor that may be involved in the regulation of immunological and inflammatory responses. This gene has been implicated in the lymph node metastasis of breast cancer.
Rabbit Anti-CCBP2 antibody recognizes human CCBP2.
Rabbit polyclonal anti-CCBP2 reacts with human chemokine binding protein-2.

免疫原

Synthetic peptide directed towards the N terminal region of human CCBP2

应用

Rabbit Anti-CCBP2 antibody can be used for immunohistochemistry (4-8μg/ml, using paraffin-embedded tissues) and western blot (0.25μg/ml) applications.
Rabbit polyclonal anti-CCBP2 is used to tag chemokine binding protein-2 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of chemokine binding protein-2 in the resolution phase of the in vivo inflammatory response via the binding/scavenging of proinflammatoy cytokines.

生化/生理作用

CCBP2 is a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown.This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.

特点和优势

Chemokine binding protein 2 (CCBP2, D6) is a β chemokine receptor expressed on lymphatic endothelial cells that binds a variety of proinflammatory cytokines to support the resolution phase of the in vivo inflammatory response. CCBP2/D6 is a chemokine-scavenging receptor that protects lymphatic surfaces from inflammatory CC-chemokines and minimizes interaction of inflammatory leukocytes with these surfaces.

序列

Synthetic peptide located within the following region: MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFGKVFLP

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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