产品说明
一般描述
The Chromobox domain (Cbx) gene family, consisting of Polycomb and Heterochromatin Protein 1 genes, involved in transcriptional repression, cell cycle regulation and chromatin remodeling. Polycomb group proteins are transcriptional repressors recruited to many developmental control genes. Chromobox homolog 6 (Cbx6) is a polycomb homolog which exhibits preferential binding affinity for trimethylated histone H3. Cbx6 is an essential regulator of cell fate decisions during embryogenesis.
特异性
Anti-CBX6 (AB1) polyclonal antibody reacts with chicken, canine, bovine, zebrafish, human, mouse, and rat chromobox homolog 6 (Cbx6) proteins.
免疫原
Synthetic peptide directed towards the N terminal region of human CBX6
应用
Anti-CBX6 (AB1) polyclonal antibody is used to tag Chromobox homolog 6 proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the distribution and role of Chromobox homolog 6 as a regulator of chromatin structure and cell fate decisions.
生化/生理作用
CBX6 is involved in maintaining the transcriptionally repressive state of genes. It modifies chromatin, rendering it heritably changed in its expressibility.
序列
Synthetic peptide located within the following region: FAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQK
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 44 kDa |
| species reactivity | rabbit, bovine, rat, mouse, guinea pig, human, horse, dog |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_055107 |
| UniProt登记号 | O95503 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CBX6(23466) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
