Rabbit anti-TDP1 Antibody, Affinity Purified

产品说明

免疫原

The epitope recognized by PLA0198 maps to a region between residue 1 and 50 of human tyrosyl-DNA phosphodiesterase 1 using the numbering given in entry NP_001008744.1 (GeneID 55775).

外形

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

其他说明

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an enzyme that participates in the repair of DNA strand breaks associated with topoisomerase 1 (Top1) complexes. TDP1 catalyzes the removal of Top1 from DNA via the hydrolysis of the phosphodiester bond between the tyrosine residue of Top1 and the 3′ phosphate of DNA. Removal of Top1 is then followed by DNA repair. TDP1 has been proposed to play more general roles in DNA damage repair independent of the Top1 complex. TDP1 has been shown to associate with DNA ligase IIIalpha, a component of the DNA single-stranded break repair (SSBR) machinery. It is also able to remove glycolate from 3′-phosphoglycolate termini of double-stranded breaks and a variety of other 3′- adducts. Defects in TDP1 are associated with spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1), a disease associated with peripheral axonal motor and sensory neuropathy and distal muscular atrophy.

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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