产品说明
免疫原
The epitope recognized by PLA0286 maps to a region between residue 481 and 531 of human Pyruvate Kinase Isozymes M1/M2 using the numbering given in entry NP_002645.3 (GeneID 5315).
外形
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
其他说明
Pyruvate Kinase M2 (PKM2) is a glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. PKM2 also stimulates POU5F1-mediated transcriptional activation, and plays a general role in caspase independent cell death of tumor cells [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P14618].
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity purified immunoglobulin |
| antibody product type | primary antibodies |
| 等级 | Powered by Bethyl Laboratories, Inc. |
| species reactivity | mouse, human |
| technique(s) | immunohistochemistry: 1:1,000-1:5,000 immunoprecipitation (IP): 2- 10 μg/mg western blot: 1:2,000- 1:10,000 |
| 登记号 | NP_002645.3 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | rabbit ... PKM2(5315) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
