位置:首页 > 品牌 > Sigma-Aldrich >

Monoclonal Anti-EIF4EBP1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB5300486
规格纯度
clone 11G12C11, ascites fluid
参考价格
4618.16 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The gene EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) is mapped to human chromosome 8p12.

免疫原

Purified recombinant fragment of 4EBP1 expressed in E.coli.
Mouse monoclonal antibody raised against 4E-BP1

生化/生理作用

The gene EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) encodes a translation repressor that interacts with eukaryotic translation initiation factor 4E (eIF4E). eIF4E is a multisubunit complex that recruits 40S ribosomal subunits to the 5′ end of mRNA. The interaction of the encoded binding protein with this complex inhibits translation. The phosphorylation of eIF4Ebp1 in response to stimuli such as, UV irradiation and insulin signaling, results in dissociation of this factor from the eIF4E complex, leading to initiation of translation of mRNA. The encoded protein participates in cell proliferation, apoptosis, invasion, and metastasis. It functions as an effector molecule in mTOR (mammalian target of rapamycin complex 1) signaling pathway that regulates protein synthesis. It is found to be overexpressed in hepatocellular carcinoma tissues and serves as a potential prognostic and therapeutic target.

外形

Ascitic fluid containing 0.03% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物unconjugated
抗体形式ascites fluid
antibody product typeprimary antibodies
克隆11G12C11, monoclonal
species reactivityhuman
technique(s)direct ELISA: 1:10,000
immunohistochemistry: 1:200-1:1,000
western blot: 1:500-1:2,000
同位素/亚型IgG1
运输wet ice
储存温度−20℃
Gene Informationhuman ... 4E-BP1(1978)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号