产品说明
一般描述
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. (provided by RefSeq)
Aggrecan (AGC1) is a multimodular molecule, encoded by the gene mapped on human chromosome 15q26.1. It is a large aggregating chondroitin sulfate proteoglycan of the human cartilage. The core protein of this multimodular molecule contains three globular domains (G1, G2 and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment.
免疫原
AGC1 (NP_037359, 56 a.a. ~ 155 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
PMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVF
应用
Monoclonal Anti-AGC1 antibody produced in mouse has been used in immunofluorescence analysis.
生化/生理作用
Aggrecan (AGC1) is required for proper functioning of articular cartilage. The encoded protein plays an essential role in chondroskeletal morphogenesis during development. AGC1 facilitates chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan. Mutations in aggrecan results in autosomal dominant short stature with accelerated skeletal maturation. In addition, genetic variation in the gene is also associated with the development of spondyloepiphyseal dysplasia.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in phosphate buffered saline, pH 7.4
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 2A8, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunofluorescence: suitable indirect ELISA: suitable western blot: 1-5 μg/mL |
| 同位素/亚型 | IgG1κ |
| GenBank® accession no. | NM_013227 |
| UniProt登记号 | P16112 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ACAN(176) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
