产品说明
一般描述
ABCG1 (ATP-binding cassette G1) gene is mapped to human chromosome 21q22.3. The encoded protein belongs to the G subfamily of ATP binding cassette (ABC) transporters. ABCG1 is expressed highly in neurons and glia in the central nervous system, brain, spleen and lungs.
免疫原
ABCG1 (AAH29158, 21 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
AEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNI
生化/生理作用
ABCG1 (ATP-binding cassette G1) mediates cholesterol efflux to HDL (high density lipoprotein) for reverse cholesterol transport, in order to eliminate intracellular cholesterol. The encoded protein controls the removal of excess cholesterol from peripheral tissues and transports it to the liver. Therefore, it is involved in sterol and glucose homeostasis. Deficiency of ABCG1 in mice leads to severe age-dependent pulmonary lipidosis. ABCG1 is known to be associated with a risk for Alzheimer′s disease. Deletion of ABCG1 gene in mice model has been shown to lead to excess accumulation of neutral lipids and phospholipids in hepatocytes and in macrophages. Lack of this gene decreases tumor growth and augments tumor cellular apoptosis. ABCG1 also serves as a potential candidate for affective disorders or suicidal behavior.
外形
Solution in phosphate buffered saline, pH 7.4
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 2E11, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | indirect ELISA: suitable |
| 同位素/亚型 | IgG1λ |
| GenBank® accession no. | BC029158 |
| UniProt登记号 | P45844 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ABCG1(9619) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
