产品说明
一般描述
A dimeric dilactone macrolide that is cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal properties.
A dimeric dilactone macrolide isolated from the marine sponge Theonella swinhoei. Cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal activity.
包装
10 μg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Disrupts the actin cytoskeleton
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Saito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571.
Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463.
Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19.
Doi, M., et al. 1991. J. Org. Chem. 56, 3629.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C78H132O20 |
| 分子量 | 1389.87 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | oil |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | colorless |
| 溶解性 | acetone: soluble ethanol: soluble |
| 运输 | ambient |
| 储存温度 | −20℃ |
安全信息
| 危险声明 | H413 |
| 预防措施声明 | P273 - P501 |
| 危险分类 | Aquatic Chronic 4 |
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
