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SIRT2 Inhibitor II, AK-1-CAS 330461-64-8-Calbiochem

品牌
Sigma-Aldrich
CAS
330461-64-8
货号
566331
规格纯度
The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.
参考价格
2096.01 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell permeable, benzylsulfonamide that inhibits SIRT2 activity (IC50= 12.5 µM through enzymatic assay) by targeting the SIRT2 nicotinamide binding site, but may also target SIRT1 and SIRT3 (IC50 >40 µM) with much less potency. Western analysis illustrates that treatment with AK-1 (>25 µM) leads to an increase in acetylated tubulin. AK-1 (1 to 10 µM) is shown to rescue neuronal dysfunction in two in vivo models of Huntington′s Disease (HD) in Dropshila and Caenorhabditis elegans. It also demonstrates recovery of neuronal toxicity in a primary model of HD from 1µM to 4 µM similar to that of genetic SIRT2 inhibition, and also correlates with the negative regulation of sterol biosynthesis.

包装

10 mg in Glass bottle

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Luthi-Carter, R., et al. 2010. Proc. Natl. Acad. Sci.107, 7927.
Outeiro, TF., et al. 2007. Science317, 516.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C19H21N3O5S
分子量403.45
MDL编号MFCD01122550

产品性质

质量水平100
测定>95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 off-white
溶解性DMSO: 50 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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