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SILuTMLite TIMP1, Metalloproteinase inhibitor 1 human

品牌
Sigma-Aldrich
货号
MSST0044
规格纯度
recombinant, expressed in HEK 293 cells, MS Protein Standard
参考价格
9134.92 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

SILuLite TIMP1 is a recombinant human protein expressed in human 293 cells. It consists of 184 amino acids, with a calculated molecular mass of 20.7 kDa. SILuLite TIMP1 is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications.

生化/生理作用

TIMP-1 is glycoprotein that is over-expressed in the supernatant of tissue extracts of breast, gastric, colorectal, and hepatocellular carcinomas. It belongs to the family of “tissue inhibitors of metalloproteinases,” a group of proteins that help regulate bone turnover. TIMP-1 serum levels are significantly associated with HER2 extracellular domain (ECD)-positivity and poorer disease-free survival among primary breast cancer patients with HER2 overexpression. High levels of serum TIMP-1 correlate with advanced disease and predict for poor survival in patients with multiple myeloma treated with bortezomib and/or IMiDs during their disease course.

序列

CTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA

外形

Supplied as a lyophilized powder containing phosphate buffered saline.

法律信息

SILu is a trademark of sigma-aldrich Co. LLC

基本信息

NACRESNA.12

产品性质

重组expressed in HEK 293 cells
质量水平200
测定≥98% (SDS-PAGE)
形式lyophilized powder
适用性suitable for mass spectrometry (internal calibrator)
UniProt登记号P01033
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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