产品说明
一般描述
CCL2, the most thoroughly characterized CC chemokine, is a monocyte-specific chemoattractant that was demonstrated to attract T lymphocytes and NK cells, but not neutrophils. Enhanced expression of CCL2 was demonstrated in a variety of pathologic conditions, associated with inflammation and mononuclear cell infiltration. Extensive experimental evidence suggests that CCL2 is highly expressed in atherosclerotic plaques. In a recent study, CCL2 was shown to have value as a biomarker for risk stratification in both the initial and the chronic phases after an acute coronary syndromes (ACS). In contrast to CRP, CCL2 levels may be an indicator of long-term cardiovascular risk rather than a marker of acute prognosis. In urine, CCL2 levels were directly associated to Systemic Lupus Erythematosus disease activity, making it a non-invasive biomarker (avoiding blood sampling or tissue biopsies).
免疫原
QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKTDYKDDDDKGHHHHHHHHGGQ
生化/生理作用
SILu™Lite CCL2 is a recombinant human protein expressed in human 293 cells. It is a homodimer consisting of 96 amino acids (including C-terminal polyhistidine and FLAG® tags), with a calculated molecular mass of 11 kDa. SILu Lite CCL2 is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications.
外形
Lyophilized from a solution of phosphate buffered saline.
法律信息
FLAG is a registered trademark of sigma-aldrich Co. LLC
SILu is a trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.12 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human |
| 重组 | expressed in HEK 293 cells |
| 测定 | ≥98% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | ≥98% Heavy amino acids incorporation efficiency by MS |
| technique(s) | mass spectrometry (MS): suitable |
| 适用性 | suitable for mass spectrometry (internal calibrator) |
| UniProt登记号 | P13500 |
| 储存温度 | −20℃ |
| Gene Information | human ... CCL2(6347) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
