产品说明
一般描述
A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC50 = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).
A cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC50 = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription.
包装
10 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Product does not compete with ATP.
Cell permeable: yes
Primary Target
activity against RNA Polymerase III
Reversible: no
Target IC50: 27 and 32 µM for Human and S. cerevisiae RNA Pol III
警告
Toxicity: Carcinogenic / Teratogenic (D)
制备说明
Slight warming may be necessary to achieve complete solubilization.
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Wu, L., et al. 2003. Euk. Cell2, 256.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C19H15Cl2N3O2S2 |
| 分子量 | 452.38 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: 15 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
