产品说明
一般描述
An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.
包装
10 mg in Glass bottle
Packaged under inert gas
生化/生理作用
Primary Target
RAGE
Reversible: yes
警告
Toxicity: Standard Handling (A)
序列
Ac-ELKVLMEKEL-NH2
外形
Supplied as a trifluoroacetate salt.
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Arumugam, T., et al. 2012. Clin Cancer Res.18, 4356.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C57H101N13O17S |
| 分子量 | 1272.55 |
产品性质
| 质量水平 | 200 |
| 测定 | ≥95% (HPLC) |
| 形式 | powder |
| 效能 | 2 μM IC50 |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white |
| 溶解性 | water: 5 mg/mL |
| 运输 | dry ice |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
