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PTP Inhibitor XVIII-CAS 1229246-07-4-Calbiochem

品牌
Sigma-Aldrich
CAS
1229246-07-4
货号
540216
规格纯度
The PTP Inhibitor XVIII, also referenced under CAS 1229246-07-4, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
2165.23 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC50 = 5, 5.8, 6, 16, and 18 µM, respectively), but not that of LAR even at concentrations as high as 100 µM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound′s in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal).

包装

10 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Bhattarai, B.R., et al. 2009. Bioorg. Med. Chem. Lett.19, 6161.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C19H10BrF6NO3S
分子量526.25

产品性质

质量水平100
测定≥95% (HPLC)
形式powder
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色light yellow
溶解性DMSO: 25 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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