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Protein Methyltransferase Inhibitor, AMI-5-CAS 17372-87-1-Calbiochem

品牌
Sigma-Aldrich
CAS
17372-87-1
货号
539211
规格纯度
The Protein Methyltransferase Inhibitor, AMI-5, also referenced under CAS 17372-87-1, controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
参考价格
1763.65 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).

包装

50 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Irritant (B)

其他说明

Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C29H6Br4Na2O5 · 3H2O
分子量854.00
MDL编号MFCD00005040

产品性质

质量水平100
测定≥90%
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
颜色 red-brown
溶解性water: 50 mg/mL
运输ambient
储存温度2-8℃
InChI1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2
InChI keySEACYXSIPDVVMV-UHFFFAOYSA-L

安全信息

象形图GHS07
警示用语:Warning
危险声明H317 - H319
预防措施声明P261 - P264 - P272 - P280 - P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)376.9 °F - Pensky-Martens closed cup
闪点(C)191.6 ℃ - Pensky-Martens closed cup

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