产品说明
一般描述
A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ~1 nM). Offers cardioprotection. Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.
A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks in vivo cholesterol synthesis (Ki ~1 nM). Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.
包装
25 mg in Plastic Bag(s)
Packaged under inert gas
生化/生理作用
Primary Target
AMG-CoA reductase
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Target Ki: ~1 nM inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocking in vivo cholesterol synthesis
警告
Toxicity: Environmental Hazard (N)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Kwak, B., et al. 2000. Natl. Med.6, 1399.
Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci.19, 26.
Narisawa, T., et al. 1996. Jpn. J. Cancer Res.87, 798.
Cohen, L.H., et al. 1993. Biochem. Pharmacol.45, 2203.
Koga, T., et al. 1990. Biochim. Biophys. Acta.1045, 115.
Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | crystalline solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze desiccated (hygroscopic) |
| 颜色 | white |
| 溶解性 | water: 100 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1 |
| InChI key | VWBQYTRBTXKKOG-IYNICTALSA-M |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
