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PARP Inhibitor XIV-CAS 1104546-89-5-Calbiochem

品牌
Sigma-Aldrich
CAS
1104546-89-5
货号
528824
规格纯度
The PARP Inhibitor XIV, also referenced under CAS 1104546-89-5, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
参考价格
4399.61 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable isoquinolinedione compound that potently inhibits PARP-1 activity (pIC50 = 7.35; IC50 = 45 nM) in a NAD+-competitive and reversible manner, while affecting PPAR-2 activity with a 100-fold lower potency. Selectively inhibits PARP-1-mediated cellular PAR formation and is of little effect against PAR formation in fibroblasts derived from parp-1(-/-) mice. Its in vivo application is limited by a poor aqueous solubility (~9 µM).

包装

10 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Eltze, T., et al. 2008. Mol. Pharmacol.74, 1587.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C15H12N2O2
分子量252.27
MDL编号MFCD12912397

产品性质

质量水平100
测定≥97% (sum of two isomers, HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 orange
溶解性DMSO: 10 mg/mL
运输ambient
储存温度2-8℃

安全信息

象形图GHS07
警示用语:Warning
危险声明H317
预防措施声明P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
危险分类Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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