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NF-κB Activation Inhibitor VII, CID-2858522-Calbiochem

品牌
Sigma-Aldrich
货号
480457
规格纯度
The NF-κB Activation Inhibitor VII, CID-2858522 controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
参考价格
2462.32 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable selective inhibitor of NF-κB activation induced by PKC pathway activators such as PMA (IC50 = 70 nM) in a HEK293 cell-based NF-κB luciferase reporter gene assay, by operating downstream of PKC but upstream of IKKβ, without inhibiting other NF-κB activation pathways. At 10 µM, this compound only inhibits Raf, TLK1, and JAK2 by 57%, 70%, and 53%, respectively, among a panel of 353 protein kinases. In addition, it attenuates CD3/CD28 and PMA/ionomycin-induced production of IL-2 by Jurkat T-cells (IC50<5 µM) and anti-IgM-stimulated proliferation of murine B-lymphocytes (IC50 = 2 µM).
A cell-permeable selective inhibitor of NF-κB activation induced by PKC pathway activators such as PMA (IC50 = 70 nM) in a HEK293 cell-based NF-κB luciferase reporter gene assay, by operating downstream of PKC but upstream of IKKβ, without inhibiting other NF-κB activation pathways. At 10 µM, this compound only inhibits Raf, TLK1, and JAK2 by 57%, 70%, and 53%, respectively, among a panel of 353 protein kinases. In addition, it attenuates CD3/CD28 and PMA/ionomycin-induced production of IL-2 by Jurkat T-cells (IC50<5 µM) and anti-IgM-stimulated proliferation of murine B-lymphocytes (IC50 = 2 µM).

包装

10 mg in Glass bottle

警告

Toxicity: Standard Handling (A)

其他说明

Peddibhotla, S., et al. 2010. J. Med. Chem.53, 4793.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C28H39N3O3
分子量465.63

产品性质

质量水平100
测定>95% (HPLC)
形式powder
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 off-white
溶解性DMSO: 100 mg/mL
运输wet ice
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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