产品说明
一般描述
A cell-permeable isothiourea compound that specifically, rapidly, and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with the nucleotide binding pocket of MreB and is useful for the temporal analysis of MreB function.
A cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with MreB′s nucleotide binding pocket and is useful for the temporal analysis of MreB function.
包装
25 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: yes
Primary Target
MreB
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution in DMSO, aliquot and freeze (-20°C. DMSO stock solutions are stable for up to 1 month at -20°C. Reconstitute in H₂O just prior to use; aqueous stock solutions are stable for up to 12 hr. Stable for up to 2 days in acidic medium.
其他说明
Gitai, Z., et al. 2005. Cell120, 329.
Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol.3, 167.
Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem.66, 2658.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C8H8Cl2N2S · xHCl |
| 分子量 | 235.13 (free base basis) |
| MDL编号 | MFCD00035050 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | white |
| 溶解性 | water: 2 mg/mL DMSO: 200 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H |
| InChI key | VBJNMXMOMSWRDV-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
