产品说明
一般描述
A symmetrical bis-(amino, hydroxynaphthalenedisulfonate) compound that antagonizes macrophage migration inhibitory factor against receptor binding (IC50 = 810 nM against hMIF and CD74 interaction) and is more potent than ISO-1 (Cat. No. 475837) in suppressing both MIF-induced IL-6 and IL-8 production in human foreskin fibroblasts (IC50 = 0.6 - 0.7 µM vs >5 µM) and MIF-induced MMP-3 production in human synovial fibroblasts (IC50 = 0.1 µM vs >10 µM). Shown to exhibit little cytotoxicity in human foreskin fibroblast cultures even at concentrations as high as 100 µM. Unlike MIF Antagonists I-IV, p425 targets an area at the interface of two MIF trimers, distal to the active site.
A symmetrical bis-(amino, hydroxynaphthalenedisulfonate) compound that antagonizes macrophage migration inhibitory factor against receptor binding (IC50 = 810 nM against hMIF and CD74 interaction) and is more potent than ISO-1 (Cat. No. 475837) in suppressing MIF-induced cytokines and MMP-3 productions in human fibroblasts cultures (IC50 = ≤0.7 µM vs >5 µM). Unlike MIF Antagonists I-IV, p425 targets an area at the interface of two MIF trimers, distal to the active site.
包装
2 g in Glass bottle
Packaged under inert gas
生化/生理作用
Primary Target
MIF
Reversible: yes
警告
Toxicity: Harmful (C)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Bai, F., et al. 2012. J. Biol. Chem.287, 30653.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C34H24N6Na4O16S4 |
| 分子量 | 992.80 |
| MDL编号 | MFCD00004020 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | blue |
| 溶解性 | water: 25 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| SMILES string | OC1=C(C=CC(C(S(=O)(O[Na])=O)=C2)=C1C(N)=C2S(=O)(O[Na])=O)/N=N/C3=CC=C(C=C3OC)C4=CC(OC)=C(/N=N/C5=C(O)C6=C(C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C6N)C=C5)C=C4 |
| InChI | 1S/C34H28N6O16S4.4Na/c1-55-23-11-15(3-7-19(23)37-39-21-9-5-17-25(57(43,44)45)13-27(59(49,50)51)31(35)29(17)33(21)41)16-4-8-20(24(12-16)56-2)38-40-22-10-6-18-26(58(46,47)48)14-28(60(52,53)54)32(36)30(18)34(22)42;;;;/h3-14,37-38H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4/b39-21-,40-22+;;;; |
| InChI key | UPKAWFACSJWKND-ZXFFUEEESA-J |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H350 |
| 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
| 危险分类 | Carc. 1B |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
