产品说明
一般描述
An orally bioavailable in-vivo prodrug of KMO Inhibitor I, Ro 61-8048 (Cat. No. 420360) that is shown to be metabolically unstable and slowly release Ro 61-8048 in blood and act as a neuroprotectant. Blocks KMO peripherally (IC50 = 4 µM) and sustainingly elevates kynurenic acid (KYNA) brain levels, an antagonist of excitatory amino acid receptors. Shown to prevent synaptic loss and behavioral deficits in AD and HD mouse model and increase the survival.
包装
10 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Campesan, S., et al. 2011. Chem. Biol.21, 961.
Zwilling, D., et al. 2011. Cell145, 863.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C23H26N4O6S2 |
| 分子量 | 518.61 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | powder |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | yellow |
| 溶解性 | DMSO: 5 mg/mL |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
