KLF5 Inhibitor, CID 5951923-CAS 749872-43-3-Calbiochem

产品说明

一般描述

A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC₅₀ = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr¹⁰⁶⁸ and ERK1/2-Thr²⁰²/Tyr²⁰⁴. Also, up-regulates the phosphorylation of p38 MAPK-Thr¹⁸⁰/Tyr¹⁸².
A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC₅₀ = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr¹⁰⁶⁸ and ERK1/2-Thr²⁰²/Tyr²⁰⁴. Also, up-regulates the phosphorylation of p38 MAPK-Thr¹⁸⁰/Tyr^182.

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock Solutions are stable for up to 3 months at -20°C.

其他说明

Bialkowska, A., et al. 2011. Mol. Cancer Ther.10, 2043.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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