产品说明
一般描述
A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 µM). The solid form of this compound (Cat. No. 553511) is also available.
包装
10 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Irritant (B)
外形
A 100 mM (10 mg/241 µl) solution of Rac1 Inhibitor II, Z62954982 (Cat. No. 553511) in DMSO
重悬
Following initial thaw, aliquot and freeze (-20°C).
其他说明
Ferri, N., et al. 2009. J. Med. Chem.52, 4087.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C20H21N3O5S |
| 分子量 | 415.46 |
| MDL编号 | MFCD11736677 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥93% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| 运输 | ambient |
| 储存温度 | −20℃ |
| SMILES string | CC1=CC=C(NC(C2=CC(OCC3=C(C)ON=C3C)=CC=C2)=O)C=C1S(N)(=O)=O |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 3 |
| 闪点(F) | 188.6 °F - (refers to pure substance) |
| 闪点(C) | 87 ℃ - (refers to pure substance) |
