产品说明
一般描述
A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 M) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 M), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2, the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. The solid form of this compound is also available.
包装
2 mg in Glass bottle
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
Akt
Reversible: yes
警告
Toxicity: Standard Handling (A)
外形
A 20 mM (2 mg/262 µL) solution of Akt Inhibitor X (Cat. No. 124020) in H₂O.
重悬
Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
其他说明
Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA107, 16982.
Thimmaiah, K.N., et al. 2005. J. Biol. Chem.280, 31924.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C20H25ClN2O · xHCl |
| 分子量 | 344.88 (free base basis) |
产品性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze avoid repeated freeze/thaw cycles protect from light |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| SMILES string | ClC(C=C1)=CC2=C1OC3=C(N2CCCCN(CC)CC)C=CC=C3 |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
