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HepaRGTM Cells MRP2 (-/-)

品牌
Sigma-Aldrich
货号
MTOX1020
包装型号
规格纯度
one vial
参考价格
13509.2 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

HepaRG is a human hepatoma cell line. The cells possess a pseudodiploid karyotype and have been characterized as an oval ductular bipotent hepatic cell line as they have the ability to differentiate into both biliary and hepatocyte lineages in the presence of DMSO. HepaRG MRP2 knockout cells express the major xenobiotic sensors (PXR, CAR and AhR), drug transporters, phase I and II drug metabolizing enzymes as well as key hepatic transcription factors involved in stress response pathways.

应用

See technical bulletin for detailed protocols

特点和优势

HepaRG cells are the most metabolically active human hepatocyte cell line developed to date. These the cells are suitable for a wide variety of studies for drug metabolism, CYP induction, metabolism-mediated toxicity, transporter, and hepatotoxicity. - Sigma′s HepaRG MRP2 Knockout (KO) allows investigations of drug-transporter interactions involving MRP2 in the liver.
Zinc finger nucleases (ZFN) mediated Knockout of ABCC2 (MRP2) gene.

  • The frame-shift mutation of ABCC2 gene was confirmed by fragment length analysis and DNA sequencing.
  • Loss of functionality was confirmed by loss of transport of selective substrates in sandwich culture assay.

质量

Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification, cytochrome oxidase I (COI) analysis for cell line species confirmation.

法律信息

Exhibit 1: ADME/Tox cell lines license
Exhibit 2: HepaRG limited use license
HepaRG is a trademark of BioPredic International company

基本信息

NACRESNA.81

产品性质

质量水平200
生物来源human female liver (hepatocarcinoma and hepatitis C tumor)
形式liquid
OMIM登记号601107
储存温度−196℃
Gene Informationhuman ... ABCC2(1244)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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