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Glucose Transporter Inhibitor IV, WZB117-CAS 1223397-11-2-Calbiochem

葡萄糖转运蛋白抑制剂 IV,WZB117-CAS 1223397-11-2-Calbiochem

品牌
Sigma-Aldrich
CAS
1223397-11-2
货号
400036
规格纯度
The Glucose Transporter Inhibitor IV, WZB117 controls the biological activity of Glucose Transporter.
参考价格
3124.36 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A bis-hydroxybenzoate compound that acts as a fast-acting, irreversible blocker of glucose transport by GLUT1 in red blood cells. Shown to rapidly inhibit glucose transport in cancer cells (IC50 ~ 500 nM in A549 cells) and block proliferation. Its inhibitory effects are more pronounced in hypoxic cancer cells. It binds directly to GLUT1 involving three hydrogen bonds, one each with Asn34, Arg126, and Trp412. Also shown to reduce the levels of GLUT1 protein, intracellular ATP levels, and glycolytic enzymes and increase the level of AMPK in tumor cells. Preferentially induces cell cycle arrest and causes senescence and necrosis in red blood cells and tumor cells (IC50 = 10 µM) over non cancerous cells and synergizes the anti-tumor effects of cisplatin (>Cat. No. 232120) and paclitaxel (>Cat. No. 580555). Also, effectively suppresses tumor growth in human A549 lung cancer grafted nude mice model (10 mg/kg, i.p., daily).

包装

25 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Reversible: no
Primary Target
Glut1

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. Unstable in DMSO.

其他说明

Liu. Y., et al. 2012. Mol. Cancer Ther.11, 1672.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C20H13FO6
分子量368.31
MDL编号MFCD24387113

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated
protect from light
颜色 white
溶解性ethanol: 100 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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