产品说明
一般描述
A cell-permeable dinitrobromobenzene compound that acts as a selective inhibitor of yeast Endoplasmic Reticulum Oxidase 1 (ERO1), but has somewhat weaker activity against mouse ERO1α (IC50 = 400 µM). Predicted to form thiol adducts and inhibits ERO1-dependent oxidation of thioredoxin-1 (Trx1) activity in vitro. Shown to cluster with genes involved in protein folding, glycosylation and cell wall biosynthesis, and delay carboxypeptidase Y (CPY) processing to the vacuolar form in wt-yeast cells.
包装
25 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 1 month at -20°C.
其他说明
Costanzo, M., et al. 2010. Science327, 425.
Blais, J.D., et al. 2010. J. Biol. Chem.285, 20993.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C7H5BrN2O5 |
| 分子量 | 277.03 |
| MDL编号 | MFCD00624873 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥99% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | yellow |
| 溶解性 | DMSO: 100 mg/mL (Use only fresh DMSO) |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| SMILES string | BrC(C=C(C([N+]([O-])=O)=C1)OC)=C1[N+]([O-])=O |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
