产品说明
一般描述
Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer. A potent, cell-permeable, reversible, and selective inhibitor of protein kinase C (PKC; IC50 = 2.8 µM) and insulin receptor tyrosine kinase. PKC inhibition is competitive with respect to diacylglycerol, phorbol dibutyrate, and Ca2+. Does not affect the activity of myosin light chain kinase and protein kinase A. Induces apoptosis in human leukemia HL-60 cells. Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.
包装
10 mg in Plastic ampoule
生化/生理作用
Target IC50: 2.8 µM against PKC
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
PKC
警告
Toxicity: Irritant (B)
重悬
Following reconstitution, aliquot, purge with N₂ gas, and freeze (-20°C). Stock solutions are stable for up to 6 months under inert atmosphere at -20°C.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C18H37NO2 |
| 分子量 | 299.49 |
| MDL编号 | MFCD00036751 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (TLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze |
| 颜色 | white |
| 溶解性 | chloroform: 1 mg/mL methanol: 1 mg/mL DMSO: 10 mg/mL |
| 运输 | ambient |
| 储存温度 | −20℃ |
| InChI | 1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1 |
| InChI key | WWUZIQQURGPMPG-KRWOKUGFSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
