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D-erythro-Sphingosine, Free Base, High Purity-CAS 123-78-4-Calbiochem

品牌
Sigma-Aldrich
CAS
123-78-4
货号
567726
规格纯度
Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.
参考价格
1954.93 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer. A potent, cell-permeable, reversible, and selective inhibitor of protein kinase C (PKC; IC50 = 2.8 µM) and insulin receptor tyrosine kinase. PKC inhibition is competitive with respect to diacylglycerol, phorbol dibutyrate, and Ca2+. Does not affect the activity of myosin light chain kinase and protein kinase A. Induces apoptosis in human leukemia HL-60 cells. Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.

包装

10 mg in Plastic ampoule

生化/生理作用

Target IC50: 2.8 µM against PKC
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
PKC

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot, purge with N₂ gas, and freeze (-20°C). Stock solutions are stable for up to 6 months under inert atmosphere at -20°C.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C18H37NO2
分子量299.49
MDL编号MFCD00036751

产品性质

质量水平100
测定≥98% (TLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 white
溶解性chloroform: 1 mg/mL
methanol: 1 mg/mL
DMSO: 10 mg/mL
运输ambient
储存温度−20℃
InChI1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1
InChI keyWWUZIQQURGPMPG-KRWOKUGFSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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