产品说明
一般描述
A styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor.
包装
10 mg in Glass bottle
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
CXCR7
Reversible: yes
警告
Toxicity: Standard Handling (A)
其他说明
Wijtmans, M., et al. 2011, Eur J Med Chem51, 184.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C27H35FN2O4 |
| 分子量 | 470.58 |
| MDL编号 | MFCD23136023 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥99% (HPLC) |
| 形式 | oil |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | light yellow |
| 溶解性 | DMSO: 50 mg/mL |
| 运输 | ambient |
| 储存温度 | −20℃ |
| SMILES string | O=C(N(CCC1N(C)CCC1)C/C(C)=C/C2=C(F)C=CC=C2)C3=CC(OC)=C(OC)C(OC)=C3 |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
