产品说明
一般描述
A cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50 = 32 and 46 nM against CK2α and CK2α′, respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30 nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50 = 2.6, 1.6, and 2.4 µM, in A549, HCT116, and MCF-7 cultures, respectively).
包装
10 mg in Glass bottle
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Target IC50: 32 and 46 nM for CK2&alpha
Primary Target
CK2
Reversible: yes
Secondary Target
DYRK1B, Flt-3
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Hou, Z., et al. 2012. J. Med. Chem.55, 2899.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C18H14N2O4S |
| 分子量 | 354.38 |
| MDL编号 | MFCD28127268 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥99% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: 50 mg/mL |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| SMILES string | O=C(C1=CC=C(OC)C=C1)NC2=NC=C(C3=CC=C(C(O)=O)C=C3)S2 |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
