Anti-Opioid Receptor Antibody, μ, pain

产品说明

一般描述

Opiates derived from the opium poppy, Papaver somniferum, have been used for millenia for their anti-diarrheal, analgesic and euphoric properties. More recently, endogenous peptides, enkephalins, dynorphins, and endorphins, were found to bind to the same sites as opiate alkaloids. The receptors for the classical opioids are three related GPCRs, δ, κ, and µ (also known as OP1, OP2 and OP3, respectively), that activate Gi/o to reduce intracellular cAMP levels. Although most clinically used opioids function by activation of the µ opioid receptor, agonists of spinal δ opioid receptors have antinociceptive activity that is independent of µ. In addition, activation of δ increases locomotor activity, inhibits gastrointestinal motility, and decreases respiratory frequency (Dhawan et al., 1996). Agonists for δ opioid receptors also exhibit antidepressant-like activity in animal models (Broom et al., 2002).

特异性

Other species have not been tested.
Mu Opioid receptor.

免疫原

Synthetic peptide from the C-terminus of rat Mu Opioid receptor.
Epitope: C-terminus

应用

Detect Opioid Receptor using this Anti-Opioid Receptor Antibody, µ, pain validated for use in IC, IH & WB.
Research Sub Category
Neuroinflammation & Pain
Research Category
Neuroscience
Immunohistochemistry:
1:2,500-1:5,000 dilution of a previous lot was used.

Western blot:
1:1,000 dilution of a previous lot was used.

Immunocytochemistry:
1:2,500-1:5,000 dilution of a previous lot was used.

Optimal working dilutions must be determined by the end user.

质量

Evaluated by Western Blot on Human Liver lysate.

Western Blot Analysis:
1:500 dilution of this antibody detected Opioid Receptor on 10 µg of Human Liver lysate.

目标描述

45 kDa

外形

Rabbit polyclonal serum in buffer containing 0.05% sodium azide.
Unpurified

储存及稳定性

Stable for 1 year at -20ºC from date of receipt.

分析说明

Control
Spinal cord, liver lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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