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Anti-Interleukin-6 (IL-6) Antibody, clone 1G3

品牌
Sigma-Aldrich
货号
MABF41
规格纯度
clone AB42_51.38C8.1G3, from mouse
参考价格
4848.93 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Interleukin-6 (IL-6) is a pro-inflammatory cytokine that seems to be involved in the late stages of CTL generation. Other biological functions also include amplification and the inflammatory response. Combination therapies including IL-6 have been shown to have positive effects on specific malignant tumor types. The accumulation of IL-6 in the CNS is usually detrimental and can contribute to pathology of CNS diseases. IL-6 signaling is negatively regulated by TGF-beta, which down regulates STAT1, STAT3 and ICAM-1 expression. IL-6 expression has been linked to inflammatory bowel disease (IBD) and is also the primary clinical target for IBD. Clinical use of an antibody for the IL-6 receptor (IL-6R) has been promising in treating rheumatoid arthritis, systemic juvenile idiopathic arthritis and Castleman’s disease.

免疫原

Human IL-6 fused to the soluble domain of the IL-6R.

应用

Research Sub Category
Cytokines & Cytokine Receptors
Anti-Interleukin-6 (IL-6) Antibody, clone 1G3 is an antibody against Interleukin-6 (IL-6) for use in WB.
Research Category
Inflammation & Immunology

质量

Evaluated by Western Blot with human IL-6 recombinant protein.

Western Blot Analysis: 0.5 g/mL of this antibody detected 10 g of human IL-6 recombinant protein.

目标描述

~21 kDa observed

联系

Replaces: 04-1095

外形

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Human IL-6 recombinant protein

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
克隆AB42_51.38C8.1G3, monoclonal
species reactivityhuman
technique(s)western blot: suitable
同位素/亚型IgG2bκ
NCBI登记号NP_000591
UniProt登记号P05231
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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