产品说明
一般描述
A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
包装
10 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Platzer, B., et al. 2009. J. Immunol.183, 66.
Hauben, E., et al. 2008. Blood118, 1214.
Lawrence, B.P., et al. 2008. Blood112, 1158.
Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med.173, 599.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C17H11ClF3N3 |
| 分子量 | 349.74 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥99% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white |
| 溶解性 | DMSO: 50 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
