产品说明
一般描述
SILu™Lite SOST is a recombinant human protein expressed in human 293 cells. It consists of 201 amino acids (including a N-terminal polyhistidine and tag), with a calculated molecular mass of 22.8 kDa. SILu™Lite SOST is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications.
生化/生理作用
Sclerostin is a secreted Wnt signaling antagonist produced almost exclusively by osteocytes. It can selectively inhibit Wnt/ β-catenin, suppressing the activity of osteoblasts as well as the viability of osteoblasts and osteocytes. Lower sclerostin levels are associated with lower bone mineral content and bone. It was demonstrated that greater total limb bone mineral content was significantly associated with greater circulating levels of sclerostin. In addition, circulating sclerostin is a biomarker of osteoporosis severity in long-term, chronic paraplegia. Serum sclerostin was associated significantly, independently, and positively with bone mineral density of both cortical and cancellous bone. Sclerostin is considered to be one of the factors associated with chronic kidney disease-mineral and bone disorder in hemodialysis patients.
序列
HHHHHHHHGGQQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY
外形
Supplied as a lyophilized powder containing phosphate buffered saline.
法律信息
SILu is a trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.12 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human |
| 重组 | expressed in HEK 293 cells |
| 标签 | 8-His tagged |
| 测定 | ≥98% (SDS-PAGE) |
| 形式 | lyophilized powder |
| technique(s) | mass spectrometry (MS): suitable |
| 适用性 | suitable for mass spectrometry (internal calibrator) |
| UniProt登记号 | Q9BQB4 |
| 储存温度 | −20℃ |
| Gene Information | human ... SOST(50964) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
