产品说明
一般描述
Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is known to interact with Bcl-2 and Bax. It has been reported that Bid induces cytochrome c release from mitochondria following cleavage by caspase-8 in response to apoptotic stimuli transmitted through cell surface death receptors. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid-deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.
特异性
AB1735 recognizes Bid from human, mouse, rat and rabbit.
免疫原
Recombinant full length GST-tagged mouse Bid protein
应用
Research Category
Apoptosis & Cancer
Research Sub Category
BCL2 & Inhibition
Detect Bid using this Anti-Bid Antibody validated for use in WB, IP, IH.
Western blot: Recommended antibody dilution 1:3,000 to 1:6,000. Recognizes a band migrating at approximately 22 kDa corresponding to Bid.
Immunoprecipitation: Recommended antibody dilution 1:200
Immunohistochemistry: Recommended antibody dilution 1:1500
Optimal working dilutions must be determined by end user.
联系
Replaces: 04-438
外形
Whole serum without preservatives
储存及稳定性
Store at -20°C for up to 12 months.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | serum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| species reactivity | mouse, rabbit, rat, human |
| manufacturer/tradename | Chemicon® |
| technique(s) | immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| NCBI登记号 | NM_001196.2 NM_197966.1 NM_197967.1 |
| UniProt登记号 | P55957 |
| 运输 | dry ice |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
