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White-Clark catalyst

品牌
Sigma-Aldrich
CAS
2226663-68-7
货号
901425
包装型号
规格纯度
参考价格
599.97 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

This catalyst is useful for late-stage functionalization of complex compounds through C-H amination. This catalyst is highly reactive and selective for amination at benzylic positions. The benzylic amination is highly selective over tertiary amination. In substrates with multiple benzylic sites, the preference is for amination at the least sterically encumbered and most electron rich site, irrespective of bond dissociation energy (BDE). Substrates containing basic nitrogen (tertiary amines, pyridine, benzimidazole) can be effectively protected for the first time using this catalyst with a Brønsted (HBF4) or Lewis acid (BF3), to give remotely aminated products. Late-stage amination has been demonstrated on a series of drugs and drug-like molecules, including citalopram, analogs of estrone and dextromethorphan, and biflavanoids, many of which cannot be accessed by other amination methods due to the presence of basic nitrogens.

其他说明

Manganese-catalysed benzylic C(sp3)–H amination for late-stage functionalization

法律信息

This product is patent pending under application #62/569,872.

基本信息

经验(实验)分子式C32Cl17MnN8
分子量1154.04

产品性质

形式powder
reaction suitabilityreagent type: catalyst
core: manganese

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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