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SBHA-CAS 38937-66-5-Calbiochem

品牌
Sigma-Aldrich
CAS
38937-66-5
货号
559418
规格纯度
A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties.
参考价格
1903.37 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Causes an increase in acetylated histone H4 in MEL cells and inhibits the human HDAC1 and HDAC3 activities with a similar potency (ID50 ~ 250-300 nM). Belongs to the hybrid polar class of compounds that acts both as inducers of differentiation of transformed cells and apoptosis. Suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC50 = 11.57 µM and 5.39 µM, respectively).
A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Reported to cause an increase in acetylated histone H4 in MEL cells. Also reported to inhibit human HDAC1 and HDAC3 activities with a similar potency (ID50 ~ 250-300 nM). Belongs to the hybrid polar class of compounds that induce both differentiation of transformed cells and apoptosis. Shown to suppress the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC50 = 11.57 µM and 5.39 µM, respectively).

包装

100 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Cell permeable: yes
Primary Target
human HDAC1 and HDAC3 activities
Target IC50: 11.57 µM and 5.39 µM in suppressing the growth of proliferating keratinocytes and squamous cell carcinoma cells, respectively
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.





From Catalog:

Desc. Field- added "cell-permeable"

其他说明

Brinkmann, H., et al. 2001. J. Biol. Chem.276, 22491.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 5705.
Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA91, 10251.

法律信息

Not available for sale in the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C8H16N2O4
分子量204.22
MDL编号MFCD00192455

产品性质

质量水平100
测定≥95% (TLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 white to off-white
溶解性DMSO: 10 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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