产品说明
一般描述
Recombinant protein fragment of Human XRCC4 with N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G) fusion tag. X-ray repair cross-complementing protein 4 (XRCC4) is also known as DNA repair protein XRCC4. It is mapped to human chromosome locus 5q14.2. It mediates joining of DNA double strand breaks during DNA repair.
应用
Suitable as a blocking agent using corresponding antibodies.
生化/生理作用
X-ray repair cross-complementing protein 4 (XRCC4) interacts with XRCC4-like factor (XLF) and DNA ligase IV in mediating nonhomologous end joining (NHEJ) cascade in DNA repair. A mutation in the XRCC4 is associated with adult-onset progressive encephalocardiomyopathy and ataxia. Patients with polymorphisms in XRCC4 gene are susceptible to schizophrenia. Single nucleotide polymorphisms in XRCC4 associates with high risk for cancer development. Mutations in XRCC4 leads to growth failure resulting in short stature accompanied by facial dysmorphism.(10)
联系
Corresponding Antibody HPA006801.
外形
Solution in 1 M urea-PBS, pH 7.4
制备说明
The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.
法律信息
Prestige Antigens is a trademark of sigma-aldrich Co. LLC
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
产品性质
| 质量水平 | 100 |
| 重组 | expressed in E. coli |
| 测定 | >80% (SDS-PAGE) |
| 形式 | buffered aqueous solution |
| 分子量 | predicted mol wt 33 kDa |
| 纯化方式 | immobilized metal affinity chromatography (IMAC) |
| 浓度 | ≥0.5 mg/mL |
| 免疫原序列 | KCVSAKEALETDLYKRFILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQTDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEK |
| 基因组数据库 |人类登记号 | ENSG00000152422 |
| UniProt登记号 | Q13426 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... XRCC4(7518) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
