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Nifuroxazide-CAS 965-52-6-Calbiochem

品牌
Sigma-Aldrich
CAS
965-52-6
货号
481984
规格纯度
A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity.
参考价格
1560.15 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC50 = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC50 = 10 µM against tyr705 of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser727 phosphorylation of STAT3.
A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC50 = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC50 = 10 µM against tyr705 of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser727 phosphorylation of STAT3.

包装

500 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Nelson, E.A., et al. 2008. Blood112, 5095.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C12H9N3O5
分子量275.22
MDL编号MFCD00079482

产品性质

质量水平100
测定≥97% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色bright yellow
溶解性DMSO: 5 mg/mL
运输ambient
储存温度2-8℃
InChI1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+
InChI keyYCWSUKQGVSGXJO-NTUHNPAUSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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