产品说明
一般描述
A cell-permeable, Antennapedia-NBD mutated (Trp739 → Ala and Trp741 → Ala) fusion peptide analog of NEMO-Binding Domain Binding peptide (Cat. No. 480025) that serves as a negative control. Reported to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun or DNA binding of the transcription factor Oct-1.
A cell-permeable Antennapedia-NBD mutated (Trp739 and Trp741 replaced with Ala) fusion peptide analog of NEMO-Binding Domain Binding Peptide (Cat. No. 480025) that serves as a negative control. Shown to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun and DNA binding of the transcription factor Oct-1.
包装
500 μg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
Negative control defective in binding to NEMO
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Standard Handling (A)
序列
H₂N-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Ala-Ser-Ala-Leu-Gln-Thr-Glu-OH
其他说明
This peptide will precipitate when added to tissue culture medium even at 100 µM concentrations; however, sufficient material will stay in solution to permeate cells.
Jimi, E., et al. 2004. Nat. Med., 10, 617.
May, M.J., et al. 2000. Science289, 1550.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C154H249N47O42S |
分子量 | 3462.98 |
产品性质
质量水平 | 100 |
测定 | ≥95% (HPLC) |
形式 | lyophilized solid |
manufacturer/tradename | Calbiochem® |
储存条件 | OK to freeze desiccated (hygroscopic) |
颜色 | off-white |
溶解性 | DMSO: 50 mg/mL |
运输 | ambient |
储存温度 | −20℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |