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InSolution Smoothened Agonist, SAG-Calbiochem

InSolution Smoothened 激动剂,SAG-Calbiochem

品牌
Sigma-Aldrich
货号
566661
规格纯度
InSolution Smoothened Agonist, SAG, is a 10 mM (500 μg/86 μl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H2O.
参考价格
2167.01 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50 ∼3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.

包装

500 μg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

外形

A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H₂O.

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Meloni, A.R., et al. 2006. Mol. Cell. Biol.26, 7750.
Chen, W., et al. 2004. Science306, 2257.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C28H28ClN3OS · 2HCl · xH2O
分子量562.98 (anhydrous basis)

产品性质

质量水平100
测定≥95% (HPLC)
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
运输wet ice
储存温度−20℃

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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