产品说明
一般描述
A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC50 ~ 400 nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2α phosphorylation and increase chaperone availability by attenuating translation.
包装
250 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Tsaytler, P., et al. 2011. Science332, 91.
Erb, S., et al. 2000. Neuropsychopharmacology23, 138,
Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol.327, 1.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C8H8Cl2N4 · xC2H4O2 |
| 分子量 | 231.08 (free base basis) |
| MDL编号 | MFCD00153801 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥99% (HPLC) |
| 形式 | powder |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | white |
| 溶解性 | water: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+; |
| InChI key | MCSPBPXATWBACD-GAYQJXMFSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H301 |
| 预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 |
| 危险分类 | Acute Tox. 3 Oral |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
