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GST M1-1, Recombinant Human

品牌
Sigma-Aldrich
货号
GS65
包装型号
规格纯度
参考价格
5525.7 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual′s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
Glutathione S-transferase mu 1 (GSTM1) is an enzyme that in humans is encoded by the GSTM1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

储存及稳定性

The enzyme should be used by the end-user customer within 1 year of receipt.

基本信息

NACRESNA.26

产品性质

质量水平100
生物来源human
重组expressed in E. coli
测定>95% (SDS-PAGE)
形式frozen liquid
specific activity97.96 units/mg protein (using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.)
分子量 26 kDa
浓度3.1 mg/mL
储存温度−70℃
Gene Informationhuman ... GSTM1(2944)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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