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GGTI-286-CAS 171744-11-9-Calbiochem

品牌
Sigma-Aldrich
CAS
171744-11-9
货号
345878
规格纯度
A potent, cell-permeable, and selective inhibitor of GGTase I.
参考价格
2741.8 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A potent, cell-permeable, and selective GGTase-I inhibitor. This methyl ester derivative of GGTI-287 (Cat. No. 345880) is 25-fold more potent (IC50 = 2 µM versus 50 µM) than FTI-277 (Cat. No. 344555) inhibiting the processing of the geranylgeranylated protein Rap1A. Selectively antagonizes oncogenic K-Ras4B (IC50 = 2 µM). GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells.
A potent, cell-permeable, and selective inhibitor of GGTase I. This methyl ester derivative of GGTI-287 (Cat. No. 345880) is about 25-fold more potent (IC50 = 2 µM vs. 50 µM) than FTI-277 (Cat. No. 344555) in inhibiting the processing of the geranylgeranylated protein Rap1A. Selectively antagonizes oncogenic K-Ras4B (IC50 = 2 µM). GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells.

包装

250 μg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Target IC50: 2 µM against GGTase
Product does not compete with ATP.
Cell permeable: yes
Primary Target
Geranylgeranyltransferase (GGTase)
Reversible: no

警告

Toxicity: Standard Handling (A)

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.

其他说明

Bredel, M., et al. 1998. Neurosurgery 43, 124.
Qian, Y., et al. 1998. Bioorg. Med. Chem.6, 293.
Lerner, E.C., et al. 1997. Oncogene 15, 1283.
Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26770.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C23H31N3O3S
分子量429.58

产品性质

质量水平100
测定≥90% (HPLC)
形式solid (Glassy)
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
溶解性DMSO: 10 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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