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Dicoumarol-CAS 66-76-2-Calbiochem

品牌
Sigma-Aldrich
CAS
66-76-2
货号
287897
规格纯度
A cell-permeable quinone reductase inhibitor with anticoagulant properties.
参考价格
1164.01 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable quinone reductase inhibitor with anticoagulant properties. Potentiates apoptosis by simultaneously blocking SAPK/JNK and NF-κB pathways. Does not affect phosphorylation of p38 or activation of AKT. Blocks brefeldin A-dependent mono-ADP-ribosylation in vitro and Golgi disassembly in living cells (IC50 = 180 µM and 150 µM, respectively).
A cell-permeable quinone reductase inhibitor with anti-coagulant properties. Binds competitively with NADH or NADPH to inhibit NAD(P)H:quinone oxidoreductase (NQO1). Shown to inhibit IGF-I-, menadione-, and DMNQ-mediated activation of stress-activated protein kinase/c-jun NH2-terminal kinase (SAPK/JNK) and subsequent phosphorylation of c-Jun, as well as stress-induced activation (hypertonic sorbitol) of SAPK/JNK. Does not affect p38 phosphorylation or protein kinase B (AKT) activation. Also shown to induce apoptosis in MCF7 breast carcinoma cells. Inhibits glutathione-S transferase (GST) A1-1 enzyme (Kiu = 4.4 µM, Kic = 3.6 µM) in vitro and in MCF7/VPα cells (a multidrug resistant derivative of MCF7 transfected with GST A1-1). Blocks brefeldin A-dependent mono-ADP-ribosylation in vitro and Golgi disassembly in living cells (IC50 = 180 µM and 150 µM, respectively).

包装

500 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Target IC50: 180 µM and 150 µM in blocking brefeldin A-dependent mono-ADP-ribosylation in vitro and Golgi disassembly in living cells, respectively
Primary Target
Blocks brefeldin A-dependent mono-ADP-ribosylation in vitro
Product does not compete with ATP.
Cell permeable: yes
Reversible: no

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

重悬

Unstable in solution; reconstitute just prior to use.

其他说明

Seanor, K.L., et al. 2003. Antioxid. Redox. Signal5, 103.
Krause, D., et al. 2001. J. Biol. Chem.276, 19244.
Pink, J.J., et al. 2000. J. Biol. Chem.275, 5416.
Cross, J.V., et al. 1999. J. Biol. Chem.274, 31150.
Morrow, C.S., et al. 1998. J. Biol. Chem.273, 20114.
Weigert, R., et al. 1997. J. Biol. Chem.272, 14200.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C19H12O6
分子量336.29
MDL编号MFCD00006857

产品性质

质量水平100
测定≥98% (titration)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性0.1 M NaOH: 15 mg/mL
pyridine: 50 mg/mL
运输ambient
储存温度2-8℃

安全信息

象形图GHS06GHS08GHS09
警示用语:Danger
危险声明H301 - H372 - H411
预防措施声明P260 - P264 - P270 - P273 - P301 + P310 - P314
危险分类Acute Tox. 3 Oral - Aquatic Chronic 2 - STOT RE 1 Oral
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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