产品说明
一般描述
An amyloidophylic dye that specifically stains stacked β sheet aggregates. Useful for staining and visual detection of amyloid deposits. Does not bind to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the metabolism of the normal isoform. It is also shown to inhibit Pot1 Binding to Telomeric DNA.
An amyloidophylic dye that specifically stains stacked β sheet aggre-gates. Useful for staining and visual detection of amyloid deposits in nerve tissue. Binds to amyloid fibrils but not to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the normal isoform possibly through overstabilization of the conformation. It is also shown to inhibit Pot1 Binding to Telomeric DNA.
包装
500 mg in Glass bottle
生化/生理作用
Primary Target
An amyloidophylic dye that specifically stains stacked β sheet aggregates
Product does not compete with ATP.
Reversible: no
Cell permeable: no
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).
其他说明
Altschuler, S.E., et al. 2012. Biochemistrin press.
Khurana, R., et al. 2001. J. Biol. Chem.276, 22715.
Fezoui, Y., et al. 2000. Amyloid7, 166.
Fezoui, Y., et al. 2000. Nat. Struct. Biol.7, 1095.
Kramport, M., et al. 2000. Chem. Biol.7, 855.
Kuner, P., et al. 2000. J. Biol. Chem.275, 1673.
Caspi, S., et al. 1998. J. Biol. Chem.273, 3484.
Caughey, B., and Race, A.E. 1992. J. Neurochem.59, 768.
Taylor, D.L., et al. 1974. J. Histochem. Cytochem.22, 1105.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C32H22N6O6S2 · 2Na |
| 分子量 | 696.66 |
| MDL编号 | MFCD00004028 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥75% dye basis |
| 形式 | crystalline solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | rust |
| 溶解性 | water: 10 mg/mL ethanol: soluble |
| 运输 | ambient |
| 储存温度 | 15-25℃ |
| InChI | 1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2 |
| InChI key | IQFVPQOLBLOTPF-UHFFFAOYSA-L |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H350 - H361d |
| 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
| 危险分类 | Carc. 1B - Repr. 2 |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
