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Anti-HOXC10 (AB2) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
AV39274
规格纯度
affinity isolated antibody
参考价格
6305.78 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

HOX proteins are transcription factors involve in spatial and temporal order critical to body patterning (axial patterning) and limb development during embryonic development. HOXC10, an orthologues of the Abdominal-B gene of Drosophila, is a homeoprotein that is critical for development of the spinal cord and formation of neurons. HOXC10 is a good candidate maker for discrimination of mesenchymal stem cells (MSC) from unrestricted somatic stem cells (USSC). HOXC10 is overexpressed in breast cancer.

特异性

Anti-HOXC10 (AB2) polyclonal antibody reacts with canine, rat, mouse, and human Homeobox C10 proteins.

免疫原

Synthetic peptide directed towards the N terminal region of human HOXC10

应用

Anti-HOXC10 (AB2) polyclonal antibody is used to tag the Homeobox C10 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of Homeobox C10 in body pattern development during embryogenesis. Detection of HOXC10 may also be use to help differentiate stem cell populations and cancer cells.

生化/生理作用

HOXC10 belongs to the homeobox family. The homeobox family is a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation.This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation.

序列

Synthetic peptide located within the following region: MTCPRNVTPNSYAEPLAAPGGGERYSRSAGMYMQSGSDFNCGVMRGCGLA

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 38 kDa
species reactivityrabbit, guinea pig, rat, human, mouse
浓度0.5 mg - 1 mg/mL
technique(s)immunohistochemistry: suitable
western blot: suitable
NCBI登记号NP_059105
UniProt登记号Q9NYD6
运输wet ice
储存温度−20℃
Gene Informationhuman ... HOXC10(3226)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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