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4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl (bromoethyl)carbamate

品牌
Sigma-Aldrich
货号
911887
包装型号
规格纯度
参考价格
2490.2 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

This benzyl boronate tag is a synthetic means for the subcellular targeting of cargo to the nucleus. Intracellular targeting can be important for understanding the localization of metabolites, proteins, or chemical probes or to increase therapeutic efficacy by concentrating a drug at its site of action and reducing off-target effects. Localization specifically to the nucleus is typically achieved using peptide localization signals and/or relies on passive diffusion. It was recently demonstrated, however, that nuclear targeting could be accomplished instead with a small-molecule motif benzyl boronic acid via synergistic active and passive transport processes. Tang, et al, presented examples using this tag to deliver proteins to the nucleus by the importin α/β pathway, including fluorescent proteins, ribonuclease A (RNase A), and chymotrypsin. The conjugation of this nucleus-targeting building block to other proteins or small molecules will facilitate nuclear localization in varied chemical biology experiments.

其他说明

Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags

基本信息

经验(实验)分子式C16H23BBrNO4
分子量384.07

产品性质

形式liquid
储存温度2-8℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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