产品说明
应用
2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as "undruggable," or difficult-to-target, proteins. This fragment electrophile, or "scout" fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC® molecules for targeted protein degradation as demonstrated by the Cravatt Lab Lab for E3 ligase discovery.
其他说明
Technology Spotlight: Proteomic Ligandability Assessment
The Proteome-Wide Potential for Reversible Covalency at Cysteine
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
Proteome-wide covalent ligand discovery in native biological systems
法律信息
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
基本信息
经验(实验)分子式 | C12H14ClNO2 |
分子量 | 239.70 |
MDL编号 | MFCD09376367 |
产品性质
质量水平 | 100 |
测定 | ≥95% |
形式 | chunks |
储存温度 | 2-8℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |